منابع مشابه
Stability puzzles in phage lambda.
In the absence of RecA-mediated cleavage of the repressor, the lambda prophage is exceptionally stable. We develop a stochastic model that predicts the stability of such epigenetic states from affinities of the molecular components. We find that the stability, in particular, depends on the maximum possible cI protein production, and on the number of translated cro proteins per transcribed mRNA....
متن کاملBifurcation Analysis for Phage Lambda with Binding Energy Uncertainty
In a phage λ genetic switch model, bistable dynamical behavior can be destroyed due to the bifurcation caused by inappropriately chosen model parameters. Since the values of many parameters with biological significance often cannot be accurately acquired, it is thus of fundamental importance to analyze how and to which extent the system dynamics is influenced by model parameters, especially tho...
متن کاملWhat has phage lambda ever done for us?
Shortly after the dawn of biochemical genetics, Escherichia coli K-12 replaced Neurospora crassa as the key model organism. With E. coli K-12 came another, even simpler, system: each bacterial cell contained a dormant virus (bacteriophage) called lambda (λ). Occasionally, the quiescent λ genome was activated to generate free phage particles. Thus it was discovered that phage λ propagates by two...
متن کاملA programme for the construction of a lambda phage.
Infection of a sensitive host by the lambdoid coliphages can cause death of the bacterial cell by lysis or can lead to a lysogenic cell, with the viral DNA stably integrated into the host chromosome. These alternative responses both require the coordination of several host and phage functions, and lambda infection follows a well controlled developmental plan. The lytic and lysogenic pathways of...
متن کاملconstructing a dna ladder range for lambda phage by multiplex pcr
background and objectives: dna ladder contains dna fragments of different length but with known size, used to determine the size of unknown dna molecules. different dna ladders are available for expected dna length. conserved sequences were selected for design of primers to generate dna fragments of known specific size. materials and methods: in this study, we describe a method by which dna lad...
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ژورنال
عنوان ژورنال: Biotechnology(Faisalabad)
سال: 2012
ISSN: 1682-296X
DOI: 10.3923/biotech.2012.95.99